A 2021 fellow of American Association for the Advancement of Science, Pluth uses synthetic chemistry to enable new investigations into the chemical biology of sulfide species. His research seeks to increase understanding of the fundamental chemistry of sulfur-containing species, including hydrogen sulfide and carbonyl sulfide, while creating an interdisciplinary and diverse lab environment. He is the recipient of numerous awards and fellowships and serves as an associate vice president for research at the UO. He holds a Ph.D. from University of California, Berkeley, and was a postdoctoral fellow at Massachusetts Institute of Technology. He joined the UO faculty in 2011.